DaRe2THINK Neurovascular builds on the important work of the main DaRe2THINK trial by helping us to understand how AF causes cognitive decline and vascular dementia and if blood thinners protect the structure of the brain (and so preserve brain function), or if they impact on blood vessels throughout the body. This knowledge would improve the management of patients, not only with AF, but also similar conditions that affect the blood vessels around the body. Preventing cognitive decline and dementia is a major public health priority for the NHS.